Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Resting Heart Rate and Risk of Cardiovascular Diseases and All-Cause Death: The Kailuan Study
First author：Anxin Wang,Shuohua Chen
Corresponding author：Xiuhua Guo,Xingquan Zhao,Shouling Wu
essential_information
- Person in charge：Anxin Wang,Shuohua Chen
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20190076
- Published time：2014-10-24
2014-10-24
Published articles
Journal：PLoS ONE
Publication type: Original Contributions
IF(IF): 3.24
PMID: 25343354 Link To Pubmed Full text Download
Background And Purpose
Resting heart rate (RHR) predicts both cardiovascular and noncardiovascular death in different populations. However, the results of the association between RHR and cardiovascular diseases (CVDs) are inconsistent, especially for each subtype of CVDs. The aim of this study was to prospectively explore the relationship between RHR and CVDs including myocardial infarction (MI), ischemic stroke, and hemorrhagic stroke and all-cause death in a general population.
Method
The Kailuan study is a prospective longitudinal cohort study on cardiovascular risk factors and cardiovascular or cerebrovascular events. Hazard ratio (HR) with 95% confidence intervals (CI) were calculated using Cox regression modeling.
Conclusion
The elevated RHR was independently associated with the increased risk for MI and all-cause death, but not for all-cause CVDs, any stroke, ischemic stroke, nor hemorrhagic stroke. This indicates that the elevated RHR might be a risk marker for MI and all-cause death in general populations.
Main results
We analyzed 92,562 participants (18–98 years old) in the Kailuan Study. CVDs were developed in 1,903 people during follow-ups. In multivariate analysis with adjustment for major traditional cardiovascular risk factors, HRs of the highest quintile group compared with the lowest quintile group of RHR for all-cause CVDs, MI, any stroke, ischemic stroke, hemorrhagic stroke, and all-cause death were 1.03 (95% CI, 0.98–1.07), 1.10 (95% CI, 1.01–1.20), 1.01 (95% CI, 0.97–1.06), 1.02 (95% CI, 0.96–1.07), 1.01 (95% CI, 0.92–1.11) and 1.18, (95% CI, 1.13–1.23), respectively.