国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke

第一作者：A. Wang,J. Liu,X. Meng

通讯作者：Y. Wang

cognitive impairment ischemic stroke oxidized low-

基本信息

2017-11-17

已发表文章

发表杂志：European Journal of Neurology

发表类型: Original Contributions

影响因子(IF): 6.089

PMID: 29058792 Pubmed原文链接 全文下载

主要研究背景及目的

The association between oxidized low-density lipoprotein (oxLDL) and cognitive impairment is unclear. This study aimed to investigate the potential association between oxLDL and cognitive impairment among patients with acute ischemic stroke.

方法

We measured the levels of oxLDL and recorded the Mini-Mental State Examination (MMSE) score in patients with acute ischemic stroke who were recruited from the Study of Oxidative Stress in Patients with Acute Ischemic Stroke. Cognitive impairment was defined as an MMSE score of <24. The association between oxLDL and cognitive impairment was assessed by multivariate logistic or linear regression analysis. Other clinical variables of interest were also studied.

结论

Elevated levels of oxLDL were associated with a higher prevalence of cognitive impairment in patients with ischemic stroke.

主要结果

A total of 3726 patients [1287 (34.54%) female] were included in this study, with a mean age of 63.62±11.96 years. After adjusting for potential confounders in our logistic regression model, each SD increase in oxLDL was associated with a 26% increase in the prevalence of cognitive impairment (odds radio, 1.26; 95% confidence interval, 1.13–1.39; P < 0.0001). Similarly, higher oxLDL was associated with lower MMSE scores, with a 0.56-point decrease in MMSE score for every SD increase in oxLDL in a linear regression analysis (b = -0.56; 95% confidence interval, -0.81 to -0.32; P < 0.0001). There were no significant interactions between oxLDL and age, sex or education levels for cognitive impairment (all interactions, P > 0.05).