Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Measures of Adiposity and Risk of Stroke in China: A Result from the Kailuan Study
First author：Anxin Wang
Corresponding author：Shouling Wu,Xingquan Zhao
essential_information
- Person in charge：Anxin Wang
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20190086
- Published time：2013-04-17
2013-04-17
Published articles
Journal：PLoS ONE
Publication type: Original Contributions
IF(IF): 3.24
PMID: 23613897 Link To Pubmed Full text Download
Background And Purpose
The objective of this study was to explore the association between adiposity and risk of incident stroke among men and women.
Method
We studied the relationship between adiposity and stroke among 94,744 participants (18–98 years old) in the Kailuan study. During a follow-up of 4 years, 1,547 ischemic or hemorrhagic strokes were recorded. Measurements of adiposity included body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR). Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated from Cox regression models and each model fit was assessed using -2log-likelihood.
Conclusion
Adiposity increases the total risk of stroke and ischemic stroke, but not of hemorrhagic stroke. No clinically meaningful differences among the associations between BMI, WC, WHpR, and WHtR and stroke incidence were identified in this study.
Main results
Every measurement of adiposity was associated with the risk for total stroke and ischemic stroke, but not for hemorrhagic stroke. After adjusting for confounders and intermediates, the HR (comparing the mean of the highest quintile with that of the lowest quintile) for total stroke was 1.34(1.13–1.60) for BMI, 1.26(1.06–1.52) for WC, 1.29(1.08–1.56) for WHpR, and 1.38(1.15–1.66) for WHtR. The HR for ischemic stroke was 1.52(1.24–1.88) for BMI, 1.46(1.17–1.81) for WC, 1.40(1.12–1.74) for WHpR, and 1.62(1.29–2.04) for WHtR. The model fit for each of the indices was similar.