Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Resting heart rate and risk of hypertension: results of the Kailuan cohort study
First author：Anxin Wang,Xiaoxue Liu
Corresponding author：Jost B. Jonas,Shouling Wu
essential_information
- Person in charge：Anxin Wang,Xiaoxue Liu
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20190088
- Published time：2014-08-01
2014-08-01
Published articles
Journal：Journal of Hypertension
Publication type: Original Contributions
IF(IF): 4.844
PMID: 24879491 Link To Pubmed Full text Download
Background And Purpose
Resting heart rate (RHR) is a predictive risk factor of the development of cardiovascular diseases, but its association with arterial hypertension has remained unclear. This study investigated the relationship between RHR and new-onset hypertension (NOH) in an Asian population.
Method
The Kailuan study is a prospective longitudinal cohort study on cardiovascular risk factors and cardiovascular or cerebrovascular events. Hazard ratios with 95% confidence intervals (CIs) were calculated using Cox regression modelling.
Conclusion
Independently of other baseline parameters such as blood pressure, blood lipids and diabetes mellitus, elevated RHR significantly increases the risk of incident hypertension. Measuring RHR is helpful in predicting the risk of eventual arterial hypertension.
Main results
Out of 101 510 individuals originally included into the Kailuan study, 31 507 participants (mean age: 46.3±11.5 years) were selected with no previous arterial hypertension or cardiac arrhythmias. After a mean followup period of 3.5±0.9 years, 12 565 (39.88%) individuals developed arterial hypertension. Incidence of hypertension was 104.4, 109.7, 114.2 and 124.6 per 1000 person-years for each RHR quartile. In multivariate analysis with adjustment for blood pressure, blood lipids, diabetes mellitus and other parameters, hazard ratios for NOH increased significantly (P<0.0001) with increasing RHR quartile. Increase in RHR by 10 beats/minute was associated with an 8% increase in NOH. Individuals in the highest RHR quartile as compared with participants in the lowest quartile demonstrated a 16% greater risk of developing NOH [hazard ratio 1.16; 95% confidence interval (CI) 1.11–1.23]. There were no significant interactions between RHR and prehypertension, diabetes mellitus, age and BMI in terms of NOH risk, respectively.