国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Prevalence of Abnormal Glucose Regulation according to Different Diagnostic Criteria in Ischaemic Stroke without a History of Diabetes.

第一作者：Xinmiao Zhang

通讯作者：Yongjun Wang,Yilong Wang

ischaemic stroke；diabetes mellitus；prognosis；risk

基本信息

2018-05-22

已发表文章

发表杂志：BIOMED RESEARCH INTERNATIONAL

发表类型: Original Contributions

影响因子(IF): 3.411

PMID: 29951547 Pubmed原文链接 全文下载

主要研究背景及目的

We aimed to investigate the prevalence and distribution of abnormal glucose regulation, including prediabetes and newly diagnosed diabetes, according to different criteria in ischaemic stroke patients without a history of diabetes.

方法

Data were derived from a representative cohort across China. Prediabetes was defined as fasting plasma glucose (FPG) 5.6–6.9mmol/L or 2-hour oral glucose tolerance test (OGTT) 7.8–11.0mmol/L or haemoglobin A1c (HbA1c) 5.7–6.4%. Newly diagnosed diabetes was defined as FPG ≥ 7.0mmol/L, 2 h OGTT ≥ 11.1mmol/L or HbA1c ≥ 6.5%.

结论

Our study demonstrated a high prevalence of prediabetes and diabetes in ischaemic stroke patients without a history of diabetes. OGTT and HbA1c helped detect themajority of prediabetes and newly diagnosed diabetes in ischaemic stroke patients.

主要结果

Among 1251 ischaemic stroke patients, 471 (37.5%) were detected as prediabetes and 539 (43.1%) were detected as newly diagnosed diabetes. Prediabetes was present in 118 (9.4%), 290 (23.2%) and 314 (25.1%) stroke patients, and newly diagnosed diabetes was present in 138 (11.0%), 370 (29.6%), and 365 (29.2%) stroke patients, based on FPG, 2 h OGTT, and HbA1c criteria, respectively. Dependency on FPG alone would have missed 74.9% of patients in the prediabetes range and 74.4% of patients in the diabetes range.