Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Prevalence of Abnormal Glucose Regulation according to Different Diagnostic Criteria in Ischaemic Stroke without a History of Diabetes.
First author：Xinmiao Zhang
Corresponding author：Yongjun Wang,Yilong Wang
essential_information
- Person in charge：Xinmiao Zhang
- Data Sources： ACROSS-CHINA
- Number of papers：OTHERS20190094
- Published time：2018-05-22
2018-05-22
Published articles
Journal：BIOMED RESEARCH INTERNATIONAL
Publication type: Original Contributions
IF(IF): 3.411
PMID: 29951547 Link To Pubmed Full text Download
Background And Purpose
We aimed to investigate the prevalence and distribution of abnormal glucose regulation, including prediabetes and newly diagnosed diabetes, according to different criteria in ischaemic stroke patients without a history of diabetes.
Method
Data were derived from a representative cohort across China. Prediabetes was defined as fasting plasma glucose (FPG) 5.6–6.9mmol/L or 2-hour oral glucose tolerance test (OGTT) 7.8–11.0mmol/L or haemoglobin A1c (HbA1c) 5.7–6.4%. Newly diagnosed diabetes was defined as FPG ≥ 7.0mmol/L, 2 h OGTT ≥ 11.1mmol/L or HbA1c ≥ 6.5%.
Conclusion
Our study demonstrated a high prevalence of prediabetes and diabetes in ischaemic stroke patients without a history of diabetes. OGTT and HbA1c helped detect themajority of prediabetes and newly diagnosed diabetes in ischaemic stroke patients.
Main results
Among 1251 ischaemic stroke patients, 471 (37.5%) were detected as prediabetes and 539 (43.1%) were detected as newly diagnosed diabetes. Prediabetes was present in 118 (9.4%), 290 (23.2%) and 314 (25.1%) stroke patients, and newly diagnosed diabetes was present in 138 (11.0%), 370 (29.6%), and 365 (29.2%) stroke patients, based on FPG, 2 h OGTT, and HbA1c criteria, respectively. Dependency on FPG alone would have missed 74.9% of patients in the prediabetes range and 74.4% of patients in the diabetes range.