国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Prognostic Value of International Normalized Ratio in Ischemic Stroke Patients without Atrial Fibrillation or Anticoagulation Therapy.

第一作者：Xuewei Xie,Xianwei Wang

通讯作者：Yilong Wang

International normalized ratio Minor stroke Recurr

基本信息

2019-04-01

已发表文章

发表杂志：J Atheroscler Thromb

发表类型: Original Contributions

影响因子(IF): 4.928

PMID: 30318486 Pubmed原文链接 全文下载

主要研究背景及目的

The impact of international normalized ratio (INR) on prognosis after acute ischemic stroke without anticoagulation therapy is unclear. Herein, the association between baseline INR and stroke outcomes in patients without anticoagulation therapy was investigated.

方法

A total of 14,782 ischemic stroke patients from the China National Stroke Registry Ⅱ were included in this analysis. The period of follow-up was 1 year after stroke onset. Multivariate logistic regression models were used to estimate the relationship between INR and stroke outcomes including all-cause death, recurrent stroke, composite end point, and poor functional outcome.

结论

Increased admission INR was associated with adverse stroke outcomes among acute ischemic stroke patients without atrial fibrillation or anticoagulation therapy.

主要结果

Of 14,782 patients with stroke, all-cause death occurred in 1080 (7.3%), recurrence stroke in 538 (3.9%), combined end point in 1319 (8.9%), and poor functional outcome in 3001 (20.3%). Compared with the medium INR group (0.9-1.1), the odds ratios with confidence intervals of 95% for the high INR group (＞1.1) were 1.58 (1.32-1.98) for all-cause death, 1.40 (1.10-1.79) for stroke recurrence, 1.52 (1.29-1.79) for combined end point, and 1.21 (1.06-1.39) for poor functional outcome. No association between low INR (＜0.9) and any stroke outcomes was found compared with the medium group.