国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson’s disease

第一作者：Huizi Ma,Huimin Chen

通讯作者：Tao Feng

fMRI  Dentate nucleus  Parkinson’s disease 

基本信息

2015-07-10

已发表文章

发表杂志：J Neurol

发表类型: Original Contributions

影响因子(IF): 4.849

PMID: 26159100 Pubmed原文链接 全文下载

主要研究背景及目的

Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson’s disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear.

方法

To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided into tremor dominant. (TD) and non-tremor-dominant (NTD) groups. We collected resting-state fMRIs data for each subject. The bilateral DN was then chosen as the region of interest to examine PD tremor-related network changes, as well as its correlation with tremor severity.

结论

And we conclude that DN might be associated with the pathogenesis of PD tremor.

主要结果

Voxel-wise functional connectivity analysis revealed that the bilateral DN had higher connectivity with the bilateral cerebellar anterior lobe, and had lower connectivity with the bilateral prefrontal cortex in TD compared to the HC and NTD groups. Functional connectivity of the bilateral DN with the bilateral cerebellar posterior lobe was also higher in TD than NTD group. Functional connectivity between the bilateral DN and the bilateral cerebellar posterior lobe showed positive correlation with tremor severity, while that between the bilateral DN and the bilateral prefrontal cortex displayed negative correlation. Our study demonstrates higher dentato-cerebellar connectivity and lower dentatoprefrontal connectivity in TD patients, which might be involved in the pathogenesis of PD tremor.