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Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson’s disease
First author：Huizi Ma,Huimin Chen
Corresponding author：Tao Feng
essential_information
- Person in charge：Huizi Ma,Huimin Chen
- Data Sources： OTHERS
- Number of papers：OTHERS20190112
- Published time：2015-07-10
2015-07-10
Published articles
Journal：J Neurol
Publication type: Original Contributions
IF(IF): 4.849
PMID: 26159100 Link To Pubmed Full text Download
Background And Purpose
Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson’s disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear.
Method
To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided into tremor dominant. (TD) and non-tremor-dominant (NTD) groups. We collected resting-state fMRIs data for each subject. The bilateral DN was then chosen as the region of interest to examine PD tremor-related network changes, as well as its correlation with tremor severity.
Conclusion
And we conclude that DN might be associated with the pathogenesis of PD tremor.
Main results
Voxel-wise functional connectivity analysis revealed that the bilateral DN had higher connectivity with the bilateral cerebellar anterior lobe, and had lower connectivity with the bilateral prefrontal cortex in TD compared to the HC and NTD groups. Functional connectivity of the bilateral DN with the bilateral cerebellar posterior lobe was also higher in TD than NTD group. Functional connectivity between the bilateral DN and the bilateral cerebellar posterior lobe showed positive correlation with tremor severity, while that between the bilateral DN and the bilateral prefrontal cortex displayed negative correlation. Our study demonstrates higher dentato-cerebellar connectivity and lower dentatoprefrontal connectivity in TD patients, which might be involved in the pathogenesis of PD tremor.