Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Effective network of deep brain stimulation of subthalamic nucleus with bimodal positron emission tomography/functional magnetic resonance imaging in Parkinson’s disease
First author：Huimin Chen,Zhiqiang Sha
Corresponding author：Tao Feng
essential_information
- Person in charge：Huimin Chen,Zhiqiang Sha
- Data Sources： OTHERS
- Number of papers：OTHERS20190115
- Published time：2018-01-24
2018-01-24
Published articles
Journal：CNS Neurosci Ther.
Publication type: Original Contributions
IF(IF): 3.495
PMID: 29222835 Link To Pubmed Full text Download
Background And Purpose
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood.
Method
METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease. Additionally, using a functional connectivity analysis in resting-state fMRI, we investigated whether these STN-DBS-affected regions were functionally connected to constitute an effective network.
Conclusion
CONCLUSION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) may deactivate the motor cortex as a remote and network effect, affecting the target and the neighboring subcortical areas. These areas may constitute an effective network of STN-DBS modulation. Our results shed light on the mechanisms of STN-DBS treatment from a network perspective and highlight the potential therapeutic benefits of targeted network modulation.
Main results
RESULTS: The results revealed that STN-DBS reduced brain activity in the right thalamus, bilateral caudal supplementary area, and the left primary motor cortex, and it increased brain activity in the left thalamus during rest. Second, these STN-DBS-affected areas were functionally connected within an STN-DBS effective network.