Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association between Leukoaraiosis and Symptomatic Intracranial Large Artery Stenoses and Occlusions: the Chinese Intracranial Atherosclerosis (CICAS) Study
First author：Wanying Duan
Corresponding author：Liping Liu
essential_information
- Person in charge：Wanying Duan
- Data Sources： CICAS
- Number of papers：CICAS20190122
- Published time：2018-12-01
2018-12-01
Published articles
Journal：Aging and Disease
Publication type: Original Contributions
IF(IF): 6.745
PMID: 30574419 Link To Pubmed Full text Download
Background And Purpose
Leukoaraiosis (LA) is frequently found in ischemic stroke patients, especially when those patients have intracranial atherosclerosis (ICAS). However, previous studies regarding an association of LA with cerebral large artery atherosclerosis showed conflicting results, and the relationship of LA with ICAS is uncertain. This study aimed to explore the association between LA and cerebral large artery atherosclerosis in Chinese patients with cerebral ischemia.
Method
Data were derived from the Chinese Intracranial Atherosclerosis (CICAS) study. Patients diagnosed with an ischemic stroke or transient ischemic attack (TIA) within 7 days of symptom onset were included. The analysis of magnetic resonance imaging (MRI) focused on severity of LA in periventricular and deep white matter; type of cerebral large artery stenosis; and the number, severity, and distribution of ICAS lesions. ICAS was defined as an occlusion or more than 50% stenosis of intracranial vessels on magnetic resonance angiography.
Conclusion
In this nationwide prospective study, LA was associated with symptomatic ICAS, patients with multiple ICAS lesions, occlusive lesions, and atherosclerotic lesions in the posterior circulation were more likely to coexist with LA.
Main results
Among 2420 patients included, distinct LA was observed in 898 (37.11%) patients, and the rate of LA increased significantly with an increased number of risk factors. Multivariate analysis revealed that LA was independently associated with ICAS (odds ratio [OR], 1.388; 95% confidence interval [CI], 1.132– 1.702; P=0.0016). In the subgroup analysis of ICAS, LA was more frequently observed in multiple lesions (OR, 1.342; 95% CI, 1.060–1.699; P=0.0146), occlusive lesions (OR, 1.554; 95% CI, 1.214–1.998; P=0.0005), and lesions in the posterior circulation (OR, 1.360; 95% CI, 1.003–1.846; P=0.0481).