国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

A low ankle-brachial index is associated with cognitive impairment: The APAC study

第一作者：Anxin Wang,Ruixuan Jiang

通讯作者：Xingquan Zhao,Shengyun Chen

Cognition; Peripheral arterial disease; Atheroscle

基本信息

2016-11-02

已发表文章

发表杂志：Atherosclerosis

发表类型: Original Contributions

影响因子(IF): 5.162

PMID: 27835743 Pubmed原文链接 全文下载

主要研究背景及目的

Given the recognized links between atherosclerosis and cognitive impairment, the aim of this study was to examine the association between the ankle-brachial index (ABI) and cognitive impairment in a cross-sectional setting of a Chinese population.

方法

Participants (n 1⁄4 3,048, aged !40 years, 1727 men and 1321 women) were recruited from the ongoing community-based Asymptomatic Polyvascular Abnormalities Community Study. ABI was measured and a low ABI was defined as <0.9. Cognition status was evaluated via the Mini-Mental Status Exam. Multivariate logistic regression models and linear regression models were used to assess the association between ABI and cognitive impairment.

结论

A low ABI is associated with cognitive impairment, especially in non-hypertensive and diabetic patients.

主要结果

A low ABI was associated with cognitive impairment (odds ratio, OR 1⁄4 1.983; 95% confidence interval, CI: 1.150e3.419), independent of the potential confounders. In addition, a decreasing ABI (per standard deviation) was significantly associated with cognitive impairment in fully adjusted models (OR 1⁄4 1.156; CI: 1.013e1.319) and with a significant trend of decreasing MMSE scores (b 1⁄4 0.703, 95% CI 0.189e1.218, p 1⁄4 0.0074). Furthermore, the odds of a low ABI associated with cognitive impairment in participants without hypertension and participants with diabetes were 4.924 (CI: 1.860e13.035) and 6.393 (CI: 2.431e16.810), respectively.