国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2015-08-16
已发表文章
发表杂志：Journal of Psychosomatic Research
发表类型: Original Contributions
影响因子(IF): 3.006
PMID: doi: org/10.1016/j.jpsychores.2015.03.012 Pubmed原文链接 全文下载
主要研究背景及目的
Severity of stroke and disability after stroke are major predictors of post-stroke depression (PSD). The prevalence of PSD in patients with minor stroke is expected to be low because minor stroke is characterized by mild neurological dysfunction. The aim of this study was to investigate the prevalence and predictors of PSD in patients with minor ischemic stroke.
方法
Patients with first-ever minor ischemic stroke (n=757) were followed up at 14±2 days, 3 months, 6 months, and 1 year after stroke. Depression status was assessed at each follow-up. Patients that had PSD at follow-ups were classified into two groups according to the time point of the diagnosis of PSD: patients diagnosed at 14 ± 2 days formed the early-onset PSD group, and those who were diagnosed at any subsequent follow-ups constituted the late-onset PSD group.
结论
Approximately three in ten patients with first-ever minor ischemic stroke may develop depression during the first year after stroke. Female gender, smoking, mild global cognitive impairment, and stroke recurrence predict early-onset or late-onset PSD after minor ischemic stroke.
主要结果
The 1-year prevalence of PSD in patients with minor strokewas 29.0% (95% CI, 25.2–32.8). Female gender, current smoking at stroke onset, mild global cognitive impairment at 14 ± 2 days, and stroke recurrence were independently associatedwith a high risk of PSD over the 1-year follow-up. Predictors of early-onset PSD included female gender, current smoking, and mild global cognitive impairment at 14 ± 2 days, while predictors of late-onset PSD were current smoking and stroke recurrence.