国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Depression after minor stroke: the association with disability and quality of life – a 1-year follow-up study
第一作者：Yuzhi Shi
通讯作者：Chunxue Wang
2016-04-30
已发表文章
发表杂志：International Journal of Geriatric Psychiatry
发表类型: Original Contributions
影响因子(IF): 3.485
PMID: DOI: 10.1002/gps.4353 Pubmed原文链接 全文下载
主要研究背景及目的
Minor stroke is characterized by mild neurological functional impairment and relatively good outcome. Little is known about the association between post-stroke depression (PSD) and outcomes of minor stroke. The aim of this study was to investigate the association between PSD and disability and quality of life (QoL) at 1 year after minor ischemic stroke.
方法
Patients with first-ever minor ischemic stroke (n=747) were followed up at 14±2 days, 3 months, 6 months, and 1 year after stroke. Depressive symptoms were assessed at each follow-up. Patients diagnosed with depression at 14±2 days formed the early-onset PSD group; those who were diagnosed with depression at any subsequent follow-ups for the first time constituted the late-onset PSD group. The outcomes of minor stroke including disability (modified Rankin score ≥2) and QoL (Short Form-36 Health Survey) were assessed at the 1-year follow-up.
结论
Post-stroke depression was independently associated with disability and poor QoL at 1 year after first-ever minor ischemic stroke. Recovery from PSD decreased but did not eliminate the adverse impacts of PSD on outcomes of minor stroke.
主要结果
A total of 198 (26.5%) patients were diagnosed with PSD over the 1-year follow-up; 136 and 62 patients were allocated to the early-onset PSD group and late-onset PSD group, respectively. Both earlyonset and late-onset PSD were independently associated with disability and poor physical and mental health at 1 year after stroke. Recovery from depression (n=112) within 1 year decreased the adverse impacts of PSD on functional outcome and QoL.