Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis
First author：Jinhao Lyu,Ning Ma
Corresponding author：Xin Lou,Zhongrong Miao
essential_information
- Person in charge：Jinhao Lyu,Ning Ma
- Data Sources： OTHERS
- Number of papers：OTHERS20190136
- Published time：2015-11-30
2015-11-30
Published articles
Journal：Stroke
Publication type: Original Contributions
IF(IF): 7.914
PMID: 26732570 Link To Pubmed Full text Download
Background And Purpose
Three-dimensional pseudocontinuous arterial spin labeling with multiple postlabeling delays has been used to assess cerebral blood flow (CBF). We used this modality to estimate antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis.
Method
Consecutive patients with unilateral middle cerebral artery 50% to 99% stenosis at 2 centers underwent pseudocontinuous arterial spin labeling with a postlabeling delays of 1.5 and 2.5 s. Mean CBF of bilateral middle cerebral artery territory at the postlabeling delays 1.5 and 2.5 s was measured. Early-arriving flow proportion was defned as (CBF 1.5 s at lesion side/CBF 2.5 s at normal side)×100%. Late-arriving retrograde flow proportion was defned as ([CBF 2.5 s−CBF 1.5 s] at lesion side−[CBF 2.5 s−CBF 1.5 s] at normal side)/CBF 2.5 s at normal side×100%. Antegrade and collateral scales were evaluated in patients with conventional angiography. Spearman correlation coeffcients were calculated between early-arriving flow and late-arriving retrograde flow proportions on arterial spin labeling and antegrade and collateral scales on conventional angiography, respectively.
Conclusion
Three-dimensional pseudocontinuous arterial spin labeling with 2 postlabeling delays may provide an empirical approach for estimating antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis.
Main results
Forty-one patients (46.0±12.0 years) were enrolled. The mean early-arriving flow proportion was 78.3±14.9%. The mean late-arriving retrograde flow proportion was 16.1±10.2%. In 21 patients with conventional angiography, Spearman correlation coeffcient was 0.53 (95% confdence interval, 0.11–0.79) between antegrade grade and early-arriving flow proportion (P=0.01) and 0.81 (95% confdence interval, 0.56–0.92) between collateral grade and late-arriving retrograde flow proportion (P<0.0001).