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Phosphodiesterase 4D polymorphisms associate with the short-term outcome in ischemic stroke

First author：Song Yanli, Wang Chunjuan

Corresponding author：Liu Gaifen

ischemic stroke PDE4D Single nucleotide polymorp

essential_information

2017-02-22

Published articles

Journal：Scientific Reports

Publication type: Original Contributions

IF(IF): 4.379

PMID: 28225001 Link To Pubmed Full text Download

Background And Purpose

It has been demonstrated that phosphodiesterase 4D (PDE4D) genetic polymorphism is associated with ischemic stroke. However, the association between PDE4D gene and prognosis after ischemic stroke remains unknown.

Method

We consecutively enrolled ischemic stroke patients admitted to Beijing Tiantan Hospital from October 2009 to December 2013. Clinical, laboratory and imaging data upon admission were collected. All patients were followed up 3 months after stroke onset. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the associations of genetic polymorphisms with 3-month outcome after ischemic stroke and different subtypes, under various genetic models.

Conclusion

Overall, this study demonstrated that the TT genotype of SNP87 in PDE4D was associated with increased risk of poor outcome after total ischemic stroke, large-artery atherosclerosis and smallartery occlusion, in a Chinese population.

Main results

A total of 1447 patients were enrolled, and 3-month follow-up data were obtained from 1388 (95.92%). Multivariate regression analysis showed that SNP87 of PDE4D gene was associated with increased risk of unfavorable outcome after total ischemic stroke (OR=1.47, 95%CI 1.12–1.93), as well as stroke due to large-artery atherosclerosis (OR=1.49, 95%CI 1.04–2.11) and small-artery occlusion (OR=1.76, 95%CI 1.05–2.96) under a recessive model. No association between SNP83 genotype and poor outcome was found.