Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The Oxfordshire Community Stroke Project classification system predicts clinical outcomes following intravenous thrombolysis: a prospective cohort study
First author：Yuling Yang,Anxin Wang
Corresponding author：Yilong Wang,Yibin Cao
essential_information
- Person in charge：Yuling Yang,Anxin Wang
- Data Sources： TIMS-CHINA
- Number of papers：TIMS-CHINA20190146
- Published time：2016-06-29
2016-06-29
Published articles
Journal：Therapeutics and Clinical Risk Management
Publication type: Original Contributions
IF(IF): 2.423
PMID: 27418829 Link To Pubmed Full text Download
Background And Purpose
The Oxfordshire Community Stroke Project (OCSP) classification system is a simple stroke classification system that can be used to predict clinical outcomes. In this study, we compare the safety and efficacy of intravenous thrombolysis in Chinese stroke patients categorized using the OCSP classification system.
Method
We collected data from the Thrombolysis Implementation and Monitoring of Acute Ischemic Stroke in China registry. A total of 1,115 patients treated with intravenous thrombolysis with alteplase within 4.5 hours of stroke onset were included. Symptomatic intracranial hemorrhage (SICH), mortality, and 90-day functional outcomes were compared between the stroke patients with different stroke subtypes.
Conclusion
After thrombolysis, the patients with TACI exhibited greater SICH, a higher mortality rate, and worse 3-month clinical outcomes compared with the patients with non-TACI. The OCSP classification system may help clinicians predict the safety and efficacy of thrombolysis.
Main results
Of the 1,115 patients included in the cohort, 197 (17.67%) were classified with total anterior circulation infarct (TACI), 700 (62.78%) with partial anterior circulation infarct, 153 (13.72%) with posterior circulation infarct, and 65 (5.83%) with lacunar infarct. After multivariable adjustment, compared to the patients with non-TACI, those with TACI had a significantly increased risk of SICH (odds ratio [OR] 8.80; 95% confidence interval [CI] 2.84–27.25, P,0.001), higher mortality (OR 5.24; 95% CI 3.19–8.62; P,0.001), and poor functional independence (OR 0.38; 95% CI 0.26–0.56; P,0.001) at 3-month follow-up.