国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Asymptomatic Extracranial Artery Stenosis and the Risk of Cardiovascular and Cerebrovascular Diseases.

第一作者：Dandan Wang,Jing Wang

通讯作者：Xingquan Zhao,Shouling Wu,Yong Zhou

Asymptomatic Extracranial Artery Stenosis Cardiova

基本信息

2016-09-01

已发表文章

发表杂志：Scientific Reports

发表类型: Original Contributions

影响因子(IF): 4.379

PMID: 27650877 Pubmed原文链接 全文下载

主要研究背景及目的

Asymptomatic extracranial artery stenosis (ECAS), especially extracranial carotid artery stenosis, is a common disease all around the world, which affects about 7% of women and more than 12% of men in older people1. Since ECAS is one of the most important risk factors for ischemic stroke, and other vascular disease and their risk factors such as hypertension and diabetes also have strong relationship with ECAS, the early finding and management of ECAS appears to be essential in preventing and decreasing vascular diseases. However, few studies have examined the impact of asymptomatic ECAS on the risk of cardiovascular and cerebrovascular diseases in Chinese adults. We, therefore, performed a prospective study to examine whether asymptomatic ECAS and related carotid abnormality were associated with a higher risk of cardiovascular and cerebrovascular diseases.

方法

We investigated the potential associations between ECAS, carotid plaque and carotid intima-media thickness and the new occurrence of cardiovascular and cerebrovascular diseases in the study.

结论

We observed a clear relationship between ECAS and the new occurrence of cardiovascular and cerebrovascular disease, especially the brain infarction event. Carotid plaque and its instability and increased CIMT have all relevant with the occurrence of vascular events. Our findings provide direct evidence for the importance of ECAS in vascular events occurrence.

主要结果

Out of 5440 study participants, 364 showed an asymptomatic ECAS at baseline, and 185 had come up to the final vascular events (brain infarction, intracerebral hemorrhage, subarachnoid hemorrhage, coronary heart disease and death due to the vascular diseases). During the follow- up. ECAS, carotid plaque and its instability and increased CIMT have associated with vascular events significantly (P < 0.05). After adjusting relevant vascular risk factors, ECAS still has a strong relationship with the new occurrence of vascular events, especially the brain infarction (HR: 2.101; 95% CI: 1.027–4.298; P = 0.042).