Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Parkinson’s Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer
First author：Li-Jun Zuo
Corresponding author： Wei Zhang
essential_information
- Person in charge：Li-Jun Zuo
- Data Sources： OTHERS
- Number of papers：OTHERS20190151
- Published time：2015-10-02
2015-10-02
Published articles
Journal：J Clin Neurol
Publication type: Clinical and Research Innovations
IF(IF): 3.077
PMID: 26869370 Link To Pubmed Full text Download
Background And Purpose
The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson’s disease (PD) patients who experience fatigue.
Method
PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins—α-synuclein oligomer, β-amyloid (Aβ)1-42, and tau—were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients.
Conclusion
PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF.
Main results
The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders.