国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study: Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography
第一作者：Huaguang Zheng
通讯作者：Tao Feng
基本信息
- 负责人：Huaguang Zheng
- 数据来源： OTHERS
- 论文编号：OTHERS20190166
- 发表时间：2015-07-05
2015-07-05
已发表文章
发表杂志：Chinese Medical Journal (English)
发表类型: Original Contributions
影响因子(IF): 1.596
PMID: 26112718 Pubmed原文链接 全文下载
主要研究背景及目的
The relationship between monosymptomatic resting tremor (mRT) and Parkinson’s disease (PD) remains controversial.In this study, we aimed to assess the function of presynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography (DAT‑PET) and to evaluate the utility of clinical features or electrophysiological studies in differential diagnosis
方法
Thirty‑three consecutive patients with mRT were enrolled prospectively. The Unified Parkinson’s Disease Rating Scale and electromyography were tested before DAT‑PET. Striatal asymmetry index (SAI) was calculated, and a normal DAT‑PET was defined as a SAI of <15%. Scans without evidence of dopaminergic deficits (SWEDDs) were diagnosed in patients with a subsequent normal DAT‑PET and structural magnetic resonance imaging.
结论
mRT is heterogeneous in presynaptic nigrostriatal dopaminergic degeneration, which can be determined by DAT‑PET brain imaging. Clinical and electrophysiological features may provide clues to distinguish PD from SWEDDs.
主要结果
Twenty‑eight mRT patients with a significant reduction in uptake of DAT binding in the striatum were diagnosed with PD,while the remained 5 with a normal DAT‑PET scan were SWEDDs. As for UPRDS, the dressing and hygiene score, walking in motor experiences of daily living (Part II) and motor examination (Part III) were significant different between two groups (P < 0.05 and P < 0.01, respectively). Bilateral tremor was more frequent in the SWEDDs group (P < 0.05). The frequency of resting tremor and the amplitude of postural tremor tend to be higher in the SWEDDs group (P = 0.08 and P = 0.05, respectively).