Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
essential_information
2018-06-30
Published articles
Journal：STROKE
Publication type: Original Contributions
IF(IF): 7.914
PMID: 29789394 Link To Pubmed Full text Download
Background And Purpose
During the past several decades, stroke care delivery has transformed from experience-based to evidence-based practice. The rapid development of thrombolysis, endovascular therapy, and secondary prevention treatment has led to an increase in the number of clinical research studies and thus, this article will focus on the opportunities, advantages, challenges, and potential pitfalls of becoming a local PI for a large multicenter clinical trial.
Method
Clinical trials with multiple sites are necessary for studying large samples of patients to determine what therapeutic, preventative, and diagnostic products or interventions are best across multiple settings and will be effective in actual practice. Each participating site needs a local principal investigator (PI) whose guide the early career stroke physicians and researchers.
Conclusion
Open communication and mentoring, locally and as part of the clinical trials infrastructure, should be developed for early career site PIs to succeed in their important role in the advancement of clinical stroke research.
Main results
The growing number and complexity of stroke clinical trials provide early career stroke physicians with opportunities for leadership, scholarship, and partnership as site PI for multicenter clinical trials.