国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Associations between nonalcoholic fatty liver disease and ischemic stroke

第一作者：Jie Xu, Liye Dai

通讯作者：Yongjun Wang

Nonalcoholic fatty liver disease Ischemic stroke Incidence Severity

基本信息

2020-12-04

已发表文章

发表杂志：Stroke

发表类型: Article

影响因子(IF): 7.914

PMID: 33272125 Pubmed原文链接 全文下载

主要研究背景及目的

Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease and affects a considerable proportion of the general population. NAFLD is independently associated with increased risk for cardiovascular events, particularly coronary heart disease. NAFLD also appears to increase multiple risk factors for ischemic stroke. We aim to investigate the associations between nonalcoholic fatty liver disease and its severity with ischemic stroke and combined vascular events in this study.

方法

Crude and multivariable Cox proportional hazards models.

结论

The severity of NAFLD is associated with a higher risk of future ischemic stroke events.

主要结果

During a median of 10.34 years of follow-up, we documented 3490 incident stroke cases among 79,905 participants. NAFLD was found in 24,874 (31.18%) participants. Relative to participants without NAFLD at the baseline, those with NAFLD had a 16% higher risk (95% CI 1.07-1.26) of developing ischemic stroke, after adjusted for confounding variables. The HRs for patients with mild, moderate and severe NAFLD were 1.15 (95% CI 1.05–1.25), 1.19 (95% CI 1.06–1.34), and 1.21 (95% CI 1.08–1.50), respectively.