Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Associations between nonalcoholic fatty liver disease and ischemic stroke
First author：Jie Xu, Liye Dai
Corresponding author：Yongjun Wang
essential_information
- Person in charge：Jie Xu, Liye Dai
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20190198
- Published time：2020-12-04
2020-12-04
Published articles
Journal：Stroke
Publication type: Article
IF(IF): 7.914
PMID: 33272125 Link To Pubmed Full text Download
Background And Purpose
Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease and affects a considerable proportion of the general population. NAFLD is independently associated with increased risk for cardiovascular events, particularly coronary heart disease. NAFLD also appears to increase multiple risk factors for ischemic stroke. We aim to investigate the associations between nonalcoholic fatty liver disease and its severity with ischemic stroke and combined vascular events in this study.
Method
Crude and multivariable Cox proportional hazards models.
Conclusion
The severity of NAFLD is associated with a higher risk of future ischemic stroke events.
Main results
During a median of 10.34 years of follow-up, we documented 3490 incident stroke cases among 79,905 participants. NAFLD was found in 24,874 (31.18%) participants. Relative to participants without NAFLD at the baseline, those with NAFLD had a 16% higher risk (95% CI 1.07-1.26) of developing ischemic stroke, after adjusted for confounding variables. The HRs for patients with mild, moderate and severe NAFLD were 1.15 (95% CI 1.05–1.25), 1.19 (95% CI 1.06–1.34), and 1.21 (95% CI 1.08–1.50), respectively.