国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The impairment of cognition and sleep after acute ischemic stroke or transient ischemic attack in Chinese patients: design, rationale and baseline patient characteristics of a nationwide multicenter prospective registry
第一作者：yongjun wang
通讯作者：yongjun wang
基本信息
- 负责人：yongjun wang
- 数据来源： ICONS
- 论文编号：CNSR-Ⅲ20190213
- 发表时间：2020-07-13
2020-07-13
已发表文章
主要研究背景及目的
Post-stroke cognitive impairment may reduce the quality of life, and increase the risk of stroke recurrence. It is important to identify risk factors for early cognitive impairment in acute ischemic stroke patients in order to help screening post-stroke cognitive impairment patients and facilitate early adoption of appropriate treatment measures.
方法
Consecutive AIS or TIA in-hospital patients within 7 days after onset were enrolled from 40 participating sites in China. Comprehensive baseline clinical and imaging data were collected prospectively. Blood and urine samples were also collected on admission and follow-up visits. Patients were interviewed face-to-face for cognition and sleep related outcomes at 2 weeks, 3, 6 and 12 months after AIS/TIA and followed up for clinical outcomes by telephone annually over 5 years.
结论
The ICONS study is a large scale nationwide prospective registry to investigate occurrence and the longitudinal changes of cognitive impairment and sleep disorder after AIS or TIA. Data from this registry may also provide opportunity to evaluate associated factors of cognitive impairment or sleep disorder after AIS or TIA and their impact on clinical outcome.
主要结果
Between August 2015 and January 2018, a total of 2625 patients were enrolled. 92.65% patients had AIS and 7.35% patients had TIA. Overall, the average age was 61.04 years and 72.38% patients were male. Median NIHSS score was 3 in AIS patients.