Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The impairment of cognition and sleep after acute ischemic stroke or transient ischemic attack in Chinese patients: design, rationale and baseline patient characteristics of a nationwide multicenter prospective registry
First author：yongjun wang
Corresponding author：yongjun wang
essential_information
- Person in charge：yongjun wang
- Data Sources： ICONS
- Number of papers：CNSR-Ⅲ20190213
- Published time：2020-07-13
2020-07-13
Published articles
Journal：SVN
Publication type: Protocol
IF(IF): 4.765
PMID: 32665365 Link To Pubmed Full text Download
Background And Purpose
Post-stroke cognitive impairment may reduce the quality of life, and increase the risk of stroke recurrence. It is important to identify risk factors for early cognitive impairment in acute ischemic stroke patients in order to help screening post-stroke cognitive impairment patients and facilitate early adoption of appropriate treatment measures.
Method
Consecutive AIS or TIA in-hospital patients within 7 days after onset were enrolled from 40 participating sites in China. Comprehensive baseline clinical and imaging data were collected prospectively. Blood and urine samples were also collected on admission and follow-up visits. Patients were interviewed face-to-face for cognition and sleep related outcomes at 2 weeks, 3, 6 and 12 months after AIS/TIA and followed up for clinical outcomes by telephone annually over 5 years.
Conclusion
The ICONS study is a large scale nationwide prospective registry to investigate occurrence and the longitudinal changes of cognitive impairment and sleep disorder after AIS or TIA. Data from this registry may also provide opportunity to evaluate associated factors of cognitive impairment or sleep disorder after AIS or TIA and their impact on clinical outcome.
Main results
Between August 2015 and January 2018, a total of 2625 patients were enrolled. 92.65% patients had AIS and 7.35% patients had TIA. Overall, the average age was 61.04 years and 72.38% patients were male. Median NIHSS score was 3 in AIS patients.