Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association of high waist-to-height ratio with functional outcomes in patients with acute ischeimc stroke :a report from the ACROSS-China Study
First author：Ping Yu
Corresponding author：Li Guo,Yilong Wang
essential_information
- Person in charge：Ping Yu
- Data Sources： ACROSS-CHINA
- Number of papers：ACROSS-CHINA20190218
- Published time：2017-03-31
2017-03-31
Published articles
Journal：Medicine
Publication type: Original Contributions
IF(IF): 1.889
PMID: 28353610 Link To Pubmed Full text Download
Background And Purpose
The aim of our study was to investigate the relationship between the waist-to-height ratio (WHR) and all-cause mortality and functional outcomes after acute ischemic stroke in a prospective cohort study.
Method
A total of 2076 patients (36.66% females)with ischemic strokewere analyzed fromACROSS-China, which is a nationwide, prospective, hospital-based stroke registry aimed to detect the glucose abnormality in China. One-year follow-up evaluation was done by telephone interview. Outcomemeasures were all-cause mortality and functional outcome defined asmodified Rankin score being 6 and from 0 to 6, respectively. We identified predictors for functional outcomes using logistic regression analysis, and mortality outcome using Cox proportional hazardsmodel which incorporated covariates with P value of<0.2 in the univariate analysis and those of clinical importance.
Conclusion
Our findings suggest that abdominal fat accumulation may be associated with functional recovery after stroke, and is not associated with mortality after stroke. Compared with the lowest quartile, the highest quartile of WHR at admission was possibly associated with worse postacute ischemic stroke functional recovery.
Main results
The higher WHR was associated with worse functional outcome, but not predictive of the patients’ mortality outcomes. Compared with the first quartile (≤0.48), the fourth quartile of the WHR was more likely to be associated with poor functional recovery (fourth quartile (≥0.56), OR = 1.38, CI: 1.08–1.77, P = 0.01; third quartile OR = 1.10, CI: 0.86–1.40, P = 0.45; second quartile OR = 1.05, CI: 0.83–1.33, P = 0.71).