国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
2017-04-19
已发表文章
发表杂志：Neurological Research
发表类型: Original Contributions
影响因子(IF): 2.448
PMID: 28420316 Pubmed原文链接 全文下载
主要研究背景及目的
We recently measured the longitudinal use of secondary prevention medication following hospital discharge and the factors influencing persistence in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA) in China.
方法
Patients with AIS and TIA who were enrolled in the China National Stroke Registry II from June 2012 to January 2013 were surveyed to determine persistence. The medications included antiplatelet therapies, warfarin, antihypertensive therapies, statins, and diabetes medications. We determined persistence information for a 3-month period following discharge. Persistence was defined as continuation of all secondary preventive medications prescribed upon hospital discharge. The factors associated with medication persistence after 3 months of discharge were examined using multivariable logistic regression.
结论
More than half of the patients with AIS and TIA reported discontinuing one or more secondary prevention medications within 3 months of hospital discharge. Several factors associated with medication persistence were identified. Here we propose strategies that could be implemented to improve the quality of secondary prevention.
主要结果
Of the 21,592 patients with AIS and TIA, 18,344 (91.2%) were eligible for analysis. After 3 months of discharge, 46.2% of the subjects continued to take all secondary prevention medications prescribed at discharge. Independent predictors of 3-month medication persistence included younger age, absence of a history of diabetes and atrial fibrillation, higher family income, less severe stroke, the index cerebrovascular event of ischemic stroke, and being treated in a hospital with a stroke unit and more beds in the neurology department.