Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
essential_information
2017-04-19
Published articles
Journal：Neurological Research
Publication type: Original Contributions
IF(IF): 2.448
PMID: 28420316 Link To Pubmed Full text Download
Background And Purpose
We recently measured the longitudinal use of secondary prevention medication following hospital discharge and the factors influencing persistence in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA) in China.
Method
Patients with AIS and TIA who were enrolled in the China National Stroke Registry II from June 2012 to January 2013 were surveyed to determine persistence. The medications included antiplatelet therapies, warfarin, antihypertensive therapies, statins, and diabetes medications. We determined persistence information for a 3-month period following discharge. Persistence was defined as continuation of all secondary preventive medications prescribed upon hospital discharge. The factors associated with medication persistence after 3 months of discharge were examined using multivariable logistic regression.
Conclusion
More than half of the patients with AIS and TIA reported discontinuing one or more secondary prevention medications within 3 months of hospital discharge. Several factors associated with medication persistence were identified. Here we propose strategies that could be implemented to improve the quality of secondary prevention.
Main results
Of the 21,592 patients with AIS and TIA, 18,344 (91.2%) were eligible for analysis. After 3 months of discharge, 46.2% of the subjects continued to take all secondary prevention medications prescribed at discharge. Independent predictors of 3-month medication persistence included younger age, absence of a history of diabetes and atrial fibrillation, higher family income, less severe stroke, the index cerebrovascular event of ischemic stroke, and being treated in a hospital with a stroke unit and more beds in the neurology department.