Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Intracranial Atherosclerosis Burden and Stroke Recurrence for Symptomatic Intracranial Artery Stenosis (sICAS)
First author：Ping Sun, Liping Liu
Corresponding author：Dr. Yongjun Wang
essential_information
- Person in charge：Ping Sun, Liping Liu
- Data Sources： CICAS
- Number of papers：CICAS20190245
- Published time：2018-12-01
2018-12-01
Published articles
Journal：Aging and Disease
Publication type: Original Article
IF(IF): 6.745
PMID: 30574421 Link To Pubmed Full text Download
Background And Purpose
Intracranial atherosclerosis burden is an arising key index for the risk and prognosis for IntraCranial Atherosclerosis Stenosis (ICAS). The present study estimated one-year prognosis for patients of symptomatic ICAS with different degrees of intracranial atherosclerosis burden (ICASB) and identified whether the category of multiple and single acute infarction was associated with atherosclerosis burden.
Method
A total of 2864 consecutive patients, from 22 hospitals across China, who experienced an acute cerebral ischemia <7 days after onset of symptoms were evaluated. All patients underwent magnetic resonance angiography, and the degree of intracranial stenosis with the ICASB was calculated. The patients were categorized into three groups according to ICASB grading: <4, 4–5 and >5scores. Multivariate Cox proportional hazards regression models were used to estimate the impact of the hazard ratios(HR) of the putative determinants of recurrent stroke in one year.
Conclusion
Intracranial atherosclerosis burden was associated with recurrent stroke at 12 months. Multiple infarction lesions were associated with higher ICASB score which indicate higher risk of recurrent.
Main results
In the groups with ICASB 4-5 and ICASB >5scores recurrent stroke were significantly higher than the other (P<0.0001). On multivariate logistic analysis, ICASB (4-5) indicated more stroke recurrence at 12 months (adjusted hazard ratio, 1.96; 95% confidence interval, 1.08-3.56; P=0.027), compared to the ICASB<4scores and >5 groups (P<0.001). Moreover, proportion of single and multiple infarction lesions differs with different ICASB. Multiple lesions were related with higher of ICASB(P<0.001).