国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Spinal cord involvement of Churg-Strauss syndrome with multi-organ disorders
第一作者：Chenlong Yang
通讯作者：Yulun XU
基本信息
- 负责人：Chenlong Yang
- 数据来源： OTHERS
- 论文编号：OTHERS20190286
- 发表时间：2014-06-01
2014-06-01
已发表文章
主要研究背景及目的
方法
Based on the American College of Rheumatology diagnostic criteria, a diagnosis of presumed CSS was considered. Biopsy of skin, superficial peroneal nerve, and muscle revealed vascular intimal thickening and perivascular eosinophil infiltrates.
结论
Multi‑organ involvements were reported as risk factors for adverse clinical outcomes.Thus, early diagnosis based on systematic assessment and timely treatment should be particularly emphasized in order to preventfurther progression and even life‑threatening organ involvement.
主要结果
In patients with multi‑organ involvement,1000 mg intravenous methylprednisolone for 3 days, followed by 40-60 mg of prednisone daily can induce remission.Some authors advocate the use of both corticosteroid and immunosuppressors. Prognosis of CSS is generally satisfactory, and most patients respond well to corticosteroids alone.[1,5] About 20% patients experience remissions and relapses, and in such patients, continued treatment with low‑dose glucocorticoids and close observation are needed.