Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Spinal cord involvement of Churg-Strauss syndrome with multi-organ disorders
First author：Chenlong Yang
Corresponding author：Yulun XU
essential_information
- Person in charge：Chenlong Yang
- Data Sources： OTHERS
- Number of papers：OTHERS20190286
- Published time：2014-06-01
2014-06-01
Published articles
Journal：Neurol India
Publication type: Letters To Editor
IF(IF): 2.117
PMID: 25033859 Link To Pubmed Full text Download
Background And Purpose
Method
Based on the American College of Rheumatology diagnostic criteria, a diagnosis of presumed CSS was considered. Biopsy of skin, superficial peroneal nerve, and muscle revealed vascular intimal thickening and perivascular eosinophil infiltrates.
Conclusion
Multi‑organ involvements were reported as risk factors for adverse clinical outcomes.Thus, early diagnosis based on systematic assessment and timely treatment should be particularly emphasized in order to preventfurther progression and even life‑threatening organ involvement.
Main results
In patients with multi‑organ involvement,1000 mg intravenous methylprednisolone for 3 days, followed by 40-60 mg of prednisone daily can induce remission.Some authors advocate the use of both corticosteroid and immunosuppressors. Prognosis of CSS is generally satisfactory, and most patients respond well to corticosteroids alone.[1,5] About 20% patients experience remissions and relapses, and in such patients, continued treatment with low‑dose glucocorticoids and close observation are needed.