Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Anatomical localization of p53 mutated tumors: A radiographic study of human glioblastomas.
First author：Tan Zhang, Yinyan Wang
Corresponding author：Tao Jiang, Lei Wang
essential_information
- Person in charge：Tan Zhang, Yinyan Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190289
- Published time：2014-07-30
2014-07-30
Published articles
Journal：Journal of the Neurological Sciences
Publication type: Research Article
IF(IF): 3.181
PMID: 25130928 Link To Pubmed Full text Download
Background And Purpose
Method
In order to accomplish this, preoperative magnetic resonance images from 163 patients with primary glioblastomas were retrospectively analyzed. All tumors were manually marked and registered to the standard space. Using the voxel-based lesion-symptom mapping approach, voxels exhibiting the strongest correlations with p53 mutants were identified.
Conclusion
we found that p53-mutated glioblastomas were preferentially located in the frontal lobe in the area surrounding the rostral extension of the lateral ventricles. The distinct anatomical characteristics of p53-mutated and wild-type glioblastomas provide further evidence that these gliomas arise from distinct niche locations.
Main results
T-values of voxels that were greater than 95% of the permutations were factored into the results of the mapping analysis. Distinct anatomical characteristics between p53-mutated and wild-type glioblastomas were demonstrated using this approach.