国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Anatomical localization of p53 mutated tumors: A radiographic study of human glioblastomas.
通讯作者：Tao Jiang, Lei Wang
基本信息
- 负责人：Tan Zhang, Yinyan Wang
- 数据来源： OTHERS
- 论文编号：OTHERS20190289
- 发表时间：2014-07-30
2014-07-30
已发表文章
发表杂志：Journal of the Neurological Sciences
发表类型: Research Article
影响因子(IF): 3.181
PMID: 25130928 Pubmed原文链接 全文下载
主要研究背景及目的
方法
In order to accomplish this, preoperative magnetic resonance images from 163 patients with primary glioblastomas were retrospectively analyzed. All tumors were manually marked and registered to the standard space. Using the voxel-based lesion-symptom mapping approach, voxels exhibiting the strongest correlations with p53 mutants were identified.
结论
we found that p53-mutated glioblastomas were preferentially located in the frontal lobe in the area surrounding the rostral extension of the lateral ventricles. The distinct anatomical characteristics of p53-mutated and wild-type glioblastomas provide further evidence that these gliomas arise from distinct niche locations.
主要结果
T-values of voxels that were greater than 95% of the permutations were factored into the results of the mapping analysis. Distinct anatomical characteristics between p53-mutated and wild-type glioblastomas were demonstrated using this approach.