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Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas
First author：Yinyan Wan, Xing Fan
Corresponding author：Jun Ma, Tao Jiang
essential_information
- Person in charge：Yinyan Wan, Xing Fan
- Data Sources： OTHERS
- Number of papers：OTHERS20190291
- Published time：2014-12-01
2014-12-01
Published articles
Journal：Neuroradiology
Publication type: Research Article
IF(IF): 2.804
PMID: 25228449 Link To Pubmed Full text Download
Background And Purpose
Method
Preoperative magnetic resonance images were retrospectively analyzed. The lesions of each patient were segmented manually and registered to a standard brain space. Overlaying of the lesions was performed, and specific brain regions associated with PTEN loss and EGFR amplification were identified by voxel-based lesion-symptom mapping analyses.
Conclusion
Based on voxel-based imaging analyses, our results suggest that genetic changes during the tumorigenic process may have anatomical specificity. We hope that this identified correlation between these biomarkers and the anatomical distribution of glioblastomas will help enhance our understanding of the molecular mechanisms underlying glioblastoma development and progression.
Main results
A cluster located in the right frontal lobe was found to be associated with high occurrence of PTEN loss, whereas a cluster in the right parietal lobe was demonstrated to be specifically associated with high occurrence of EGFR amplification. An overlap of the two clusters was observed at the posterior portion of the right parietal lobe.