国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Effect of Blood Pressure Variability on Cardiovascular Outcome in Diabetic and Nondiabetic Patients with Stroke

第一作者：Chen Bu-Xing,Tian Jun-Ping

通讯作者：Chen Bu-Xing, Zhao Xing-Quan

Ischemic stroke; outcome; ambulatory blood pressur

基本信息

2014-10-09

已发表文章

发表杂志：Journal of Stroke and Cerebrovascular Diseases

发表类型: Research Article

影响因子(IF): 1.646

PMID: 25183559 Pubmed原文链接 全文下载

主要研究背景及目的

方法

A total of 373 ischemic stroke patients with large artery atherosclerosis were recruited and followed up. Ambulatory BP monitoring was performed in all patients and divided according to the 25th and 75th percentiles interval of SD of daytime systolic BP (SBP). Kaplan-Meier analysis and Cox regression were used to assess the relationship between BP variability and cardiovascular outcomes including stroke recurrence, vascular events and cardiovascular death.

结论

We show that SBP variability is associated with cardiovascular outcomes in stroke patients without diabetes, but we didn’t find a correlation between SBP variability and cardiovascular outcomes in stroke patients with diabetes.

主要结果

The 339 patients were included in the final analysis. During an average follow-up of 19.0 ± 5.1 months (.6-26.8 months), 69 (20.4%) cardiovascular events occurred in all patients. Kaplan-Meier analysis found that there were no differences in cardiovascular events-free survival among the different BP variability groups in diabetic patients (P = .995); however, nondiabetic patients with greater BP variability showed a lesser cardiovascular events-free survival (P = .039). Through Cox regression we found the SD of daytime SBP (hazard ratio 1.103; 95% CI 1.011-1.203) was associated with cardiovascular outcomes in nondiabetic patients with stroke.