Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis
First author：Fei-fan Xu
Corresponding author：Gilberto K.K. Leung
essential_information
- Person in charge：Fei-fan Xu
- Data Sources： OTHERS
- Number of papers：OTHERS20190309
- Published time：2015-10-01
2015-10-01
Published articles
Journal：Clinical and Translational Science
Publication type: Original Article
IF(IF): 3.989
PMID: 26077376 Link To Pubmed Full text Download
Background And Purpose
Method
We conducted an animal study to compare RADA16-I with fibrin sealant, a commonly used agent, with the hypothesis that the former would be a comparable alternative. Using a standardized surgical brain injury model, 30 Sprague-Dawley rats were randomized into three treatment groups: RADA16-I, fibrin sealant or gelatin sponge (control). Animals were sacrificed on day 3 and 42. Astrocytic and microglial infiltrations within the cerebral parenchyma adjacent to the operative site were significantly lower in the RADA16-I and fibrin sealant groups than control.
Conclusion
RADA16-I is a promising candidate for further translational and clinical studies that focus on its applications as a safe and effective hemostat, proregenerative nanofiber scaffold as well as drug and cell carrier.
Main results
RADA16-I did not cause more cellular inflammatory response despite its acidity when compared with fibrin sealant. Immunohistochemical studies showed infiltration by astrocytes and microglia into the fibrin sealant and RADA16-I grafts, suggesting their potential uses as tissue scaffolds.