Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Expression of RINT1 predicts seizure occurrence and outcomesin patients with low-grade gliomas
First author：Xing Fan,Yin-yan Wang
Corresponding author：Tao Jiang
essential_information
- Person in charge：Xing Fan,Yin-yan Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190311
- Published time：2015-04-01
2015-04-01
Published articles
Journal：Journal of Cancer Research and Clinical Oncology
Publication type: Original Article
IF(IF): 4.553
PMID: 25304616 Link To Pubmed Full text Download
Background And Purpose
Method
Clinical characteristics, RNA sequence data, and case follow-up data were reviewed for 76 patients with histologically confirmed LGG. Gene expression (n = 21,469) was compared between patients with preoperative epileptic seizures and those without preoperative epileptic seizures. The Engel classification was used at 6 months after surgery to evaluate the prognostic role of genes that passed the screen.
Conclusion
Our results suggest that high RINT1 expression may represent a risk factor for LGG-related seizures and may be associated with seizure outcomes.
Main results
Expression of RAD50 interactor 1 (RINT1) significantly differed between LGG patients with and without preoperative epileptic seizures (p = 0.003). This result was validated by applying the same analysis to RNA sequence data from The Cancer Genome Atlas (p = 0.048). Patients with high RINT1 expression were at increased risk of LGG-related seizures compared to those with low expression (p = 0.044). RINT1 was also identified as a predictor of seizure outcomes in patients with LGG at 6 months after tumor resection (p = 0.022).