国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Mapping p53 Mutations in Low-Grade Glioma:AVoxel-Based Neuroimaging Analysis

第一作者：Y.Y. Wang, T. Zhang

通讯作者：T. Jiang

Our voxel-level imaging analysis provides new evid

基本信息

2015-01-01

已发表文章

发表杂志：American Journal of Neuroradiology

发表类型: Original Research

影响因子(IF): 3.825

PMID: 25104286 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Preoperative MR images from 182 patients with histologically confirmed low-grade gliomas were retrospectively analyzed. All tumors were manually marked and registered to the standard space. Using a voxel-based lesion-symptom mapping analysis, we located brain regions associated with a high occurrence of p53 mutation and corrected them by using a permutation test. The acquired clusters were further included as a factor in survival analyses.

结论

Our voxel-level imaging analysis provides new evidence that genetic changes during cancer may have anatomic specificity. Additionally, the current study suggests that tumor location identified on structural MR images could potentially be used for customized presurgical outcome prediction.

主要结果

Statistical analysis demonstrated that the left medial temporal lobe and right anterior temporal lobe were specifically associated with high expression of mutant p53. Kaplan-Meier curves showed that tumors located in these regions were associated with significantly worse progression-free survival compared with tumors occurring elsewhere.