Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Deficiency of very large G-protein-coupled receptor-1 is a riskfactor of tumor-related epilepsy: a whole transcriptomesequencing analysis
First author：Yinyan Wang ,Xing Fan
Corresponding author：Tao Jiang ,Lei Wang
essential_information
- Person in charge：Yinyan Wang ,Xing Fan
- Data Sources： OTHERS
- Number of papers：OTHERS20190322
- Published time：2015-02-01
2015-02-01
Published articles
Journal：Journal of Neuro-oncology
Publication type: Cliniacal Study
IF(IF): 4.13
PMID: 25511798 Link To Pubmed Full text Download
Background And Purpose
Method
RNA sequence data from 80 patients with histologically confirmed LGG were collected from the Chinese glioma genome atlas database and significant differences in expression levels of 33 genes were found. One of the genes, Very large G-protein-coupled receptor-1 (VLGR1), had been previously associated with seizures. Therefore, we investigated the association between LGG-related epilepsy and VLGR1, which played a role in idiopathic epilepsy. The level of VLGR1 expression was compared between patients with epileptic seizures and those without using the reads per kilobase transcriptome per million method. To evaluate the prognostic role of VLGR1 gene expression, the progression-free survival was determined by the Kaplan-Meier method and a multivariate Cox model.
Conclusion
Based on RNA sequence data analysis, our results suggest that low expression of VLGR1 is a significant risk factor of epileptic seizures in patients with LGG.
Main results
We demonstrated that VLGR1 had a significantly lower expression level in patients with epileptic seizures compared to seizure-free patients (p = 0.003). Furthermore, VLGR1 was highly associated with the presence of seizures in a multivariate statistical model. However, VLGR1 could not serve as an independent prognostic factor to determine progression-free survival of LGG patients.