国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

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Tumor border sharpness correlates with HLA-G expression inlow-grade gliomas

第一作者：Yinyan Wang, Xing Fan

通讯作者：Yong Fan, Tao Jiang

HLA-G Low-grade glioma Sharpness of the tumor bord

基本信息

2015-03-03

已发表文章

发表杂志：J Stroke Cerebrovasc Dis

发表类型: Original Article

影响因子(IF): 2.832

PMID: 25903722 Pubmed原文链接 全文下载

主要研究背景及目的

方法

Preoperative T2-weighted images from 72 patients were retrospectively examined by manually segmenting the hyperintensive tumor areas and subsequently registering them to a standard brain template. Then, the intensity of the voxels inside the tumor border (tumor voxels) was compared with that of the voxels outside the tumor border (paratumor voxels).

结论

These findings suggest that tumors with blurred boundaries may be those prone to diffuse invasion. Additionally, patients with tumors having high HLA-G expression were less likely to have undergone complete resections. Thus, this study is the first to identify an association between HLA-G expression and the radiologic morphology of the tumor border, and may further our understanding of the role of the HLA gene in immune escape in patients with low-grade gliomas.

主要结果

The radiologic sharpness of a tumor was defined as the mean ratio of the intensity of the tumor voxels to the intensity of the paratumor voxels. Tumors with high HLA-G expression were associated with larger tumors and lower mean hyperintensive contrast.