国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study
第一作者：Runfa Tian
通讯作者：Baiyun Liu
基本信息
- 负责人：Runfa Tian
- 数据来源： OTHERS
- 论文编号：OTHERS20190331
- 发表时间：2015-07-11
2015-07-11
已发表文章
发表杂志：Biochemical and Biophysical Research Communications
发表类型: Research Report
影响因子(IF): 3.575
PMID: 26168891 Pubmed原文链接 全文下载
主要研究背景及目的
方法
We used both in vivo MRI and proton magnetic resonance spectroscopy ((1)H-MRS) to evaluate the therapeutic effect of DC on lateral controlled cortical impact (CCI) rat models at 3h, 1 d, 2 d, 3d and 7d after TBI.
结论
The present results suggest that DC can indeed reduce brain edema formation and exhibits good neuroprotective efficacy after CCI injury in rats.
主要结果
Our data suggest that DC can reduce brain edema; decrease the apparent diffusion coefficient value, contusion volume and lactate (Lac)/creatine (Cr) ratio; and increase the N-acetylaspartate (NAA)/Cr and choline (Cho)/Cr ratios after TBI.