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Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study
First author：Runfa Tian
Corresponding author：Baiyun Liu
essential_information
- Person in charge：Runfa Tian
- Data Sources： OTHERS
- Number of papers：OTHERS20190331
- Published time：2015-07-11
2015-07-11
Published articles
Journal：Biochemical and Biophysical Research Communications
Publication type: Research Report
IF(IF): 3.575
PMID: 26168891 Link To Pubmed Full text Download
Background And Purpose
Method
We used both in vivo MRI and proton magnetic resonance spectroscopy ((1)H-MRS) to evaluate the therapeutic effect of DC on lateral controlled cortical impact (CCI) rat models at 3h, 1 d, 2 d, 3d and 7d after TBI.
Conclusion
The present results suggest that DC can indeed reduce brain edema formation and exhibits good neuroprotective efficacy after CCI injury in rats.
Main results
Our data suggest that DC can reduce brain edema; decrease the apparent diffusion coefficient value, contusion volume and lactate (Lac)/creatine (Cr) ratio; and increase the N-acetylaspartate (NAA)/Cr and choline (Cho)/Cr ratios after TBI.