Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
IDH1/2 mutation is associated with seizure as an initial symptom in low-grade glioma:A report of 311 Chinese adult glioma patients
First author：Zhang Zhong
Corresponding author：Tao Jiang
essential_information
- Person in charge：Zhang Zhong
- Data Sources： OTHERS
- Number of papers：OTHERS20190336
- Published time：2015-01-01
2015-01-01
Published articles
Journal：Epilepsy Research
Publication type: Research Article
IF(IF): 3.045
PMID: 25524848 Link To Pubmed Full text Download
Background And Purpose
Method
A total of 311 adult patients with LGG were enrolled in our study with both clinical data and IDH1/2 mutation data available. IDH1/2 mutation was detected directly by pyro-sequencing. The chi-squared test was performed to determine whether the IDH1/2 mutation has any relevance to seizure onset and to evaluate the potential impact that IDH1/2 mutation may exert on seizure control postoperatively.
Conclusion
IDH1/2 mutation occurs more frequently in LGG patients with seizure as an initial symptom, suggesting a potential relationship between this genetic phenotype and clinical seizure presentation. IDH1/2 mutation shows no prognostic value for postoperative seizure control.
Main results
Seizure presented as an initial symptom in 71.4% (222/311) of patients with LGG, among which 189 patients were detected to bear IDH1/2 mutation in their tumors (P=0.035, chi-squared test). However, IDH1/2 mutation does not seem to contribute to the seizure control postoperatively (P=0.350 and 0.577 for the 6- and 12-month follow-up, respectively, chi-squared test).