国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Detection of alpha-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease
第一作者：Xuemei Wang
通讯作者：Tao Feng
基本信息
- 负责人：Xuemei Wang
- 数据来源： OTHERS
- 论文编号：OTHERS20190337
- 发表时间：2015-05-18
2015-05-18
已发表文章
主要研究背景及目的
方法
In this study, α-syn oligomer levels in red blood cells (RBCs) obtained from 100 PD patients, 22 MSA patients, and 102 control subjects were measured by enzyme-linked immunosorbent assay.
结论
The present results suggest that the RBC α-syn oligomer/total protein ratio can be a potential diagnostic biomarker for PD.
主要结果
We showed that the ratio of α-syn oligomer/total RBC protein was higher in PD patients than in controls (29.0±19.8 ng/mg vs. 15.4±7.4 ng/mg, P<0.001). The area under the receiver operating characteristic curve (AUC) indicated a sensitivity of 79.0%, specificity of 64.7% and a positive predictive value of 68.7%, with an AUC of 0.76 for increased α-syn oligomer/total RBC protein ratio. However, there was no correlation between RBC α-syn oligomer levels and age at onset, disease duration, age, UPDRS motor scale score or progression of motor degeneration in PD patients. The ratio of RBC α-syn oligomer/total protein was also higher in MSA patients than in controls (22.9±13.9 ng/mg vs. 15.4±7.4 ng/mg, P<0.001). However, no significant difference was found for α-syn oligomer/total protein ratio between PD and MSA (29.0±19.8 ng/mg vs. 22.9±13.9 ng/mg, P>0.05).