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Detection of alpha-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease
First author：Xuemei Wang
Corresponding author：Tao Feng
essential_information
- Person in charge：Xuemei Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190337
- Published time：2015-05-18
2015-05-18
Published articles
Journal：Neuroscience Letters
Publication type: Clinical Article
IF(IF): 3.046
PMID: 25998655 Link To Pubmed Full text Download
Background And Purpose
Method
In this study, α-syn oligomer levels in red blood cells (RBCs) obtained from 100 PD patients, 22 MSA patients, and 102 control subjects were measured by enzyme-linked immunosorbent assay.
Conclusion
The present results suggest that the RBC α-syn oligomer/total protein ratio can be a potential diagnostic biomarker for PD.
Main results
We showed that the ratio of α-syn oligomer/total RBC protein was higher in PD patients than in controls (29.0±19.8 ng/mg vs. 15.4±7.4 ng/mg, P<0.001). The area under the receiver operating characteristic curve (AUC) indicated a sensitivity of 79.0%, specificity of 64.7% and a positive predictive value of 68.7%, with an AUC of 0.76 for increased α-syn oligomer/total RBC protein ratio. However, there was no correlation between RBC α-syn oligomer levels and age at onset, disease duration, age, UPDRS motor scale score or progression of motor degeneration in PD patients. The ratio of RBC α-syn oligomer/total protein was also higher in MSA patients than in controls (22.9±13.9 ng/mg vs. 15.4±7.4 ng/mg, P<0.001). However, no significant difference was found for α-syn oligomer/total protein ratio between PD and MSA (29.0±19.8 ng/mg vs. 22.9±13.9 ng/mg, P>0.05).