国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas

第一作者：KE WANG, KAIBING TIAN

通讯作者：JUNTING ZHANG

Brachyury

基本信息

2015-06-22

已发表文章

发表杂志：Molecular Medicine Reports

发表类型: Original Article

影响因子(IF): 2.952

PMID: 26099340 Pubmed原文链接 全文下载

主要研究背景及目的

方法

The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients.

结论

In conclusion, the results of the present study demonstrated that the expression of Brachyury offers a sensitive marker, but not a risk factor, for skull base chordomas, and radical surgery is recommended.

主要结果

The results demonstrated that the protein expression of brachyury was negative in 8.8% (5/57) of the cases. The weak/positive, positive and strong/positive rates were 5.3% (3/57), 21.1% (12/57) and 64.9% (37/57), respectively. The association between the expression of brachyury and recurrence was not statistically significant. Kaplan‑Meier analysis revealed that the degree of surgery, rather than the expression of brachyury, was associated with tumor recurrence (P=0.001).