Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas
First author：KE WANG, KAIBING TIAN
Corresponding author：JUNTING ZHANG
essential_information
- Person in charge：KE WANG, KAIBING TIAN
- Data Sources： OTHERS
- Number of papers：OTHERS20190350
- Published time：2015-06-22
2015-06-22
Published articles
Journal：Molecular Medicine Reports
Publication type: Original Article
IF(IF): 2.952
PMID: 26099340 Link To Pubmed Full text Download
Background And Purpose
Method
The present study used immunohistochemistry to analyze 57 cases of skull base chordoma, and analyzed the clinical data of the patients.
Conclusion
In conclusion, the results of the present study demonstrated that the expression of Brachyury offers a sensitive marker, but not a risk factor, for skull base chordomas, and radical surgery is recommended.
Main results
The results demonstrated that the protein expression of brachyury was negative in 8.8% (5/57) of the cases. The weak/positive, positive and strong/positive rates were 5.3% (3/57), 21.1% (12/57) and 64.9% (37/57), respectively. The association between the expression of brachyury and recurrence was not statistically significant. Kaplan‑Meier analysis revealed that the degree of surgery, rather than the expression of brachyury, was associated with tumor recurrence (P=0.001).