Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The characteristics of post-neurosurgical bacterial meningitis in elective neurosurgery in 2012: A single institute study
First author：Runfa Tian
Corresponding author：Junting Zhang
essential_information
- Person in charge：Runfa Tian
- Data Sources： OTHERS
- Number of papers：OTHERS20190360
- Published time：2015-12-01
2015-12-01
Published articles
Journal：Clinical Neurology and Neurosurgery
Publication type: Research
IF(IF): 1.876
PMID: 26364156 Link To Pubmed Full text Download
Background And Purpose
Method
Patients with positive meningitis cultures after neurosurgical operations in our hospital during the entire year of 2012 were included in the analysis. We report demographic characteristics, morbidity during different seasons, clinical and bacteriological profiles, sensitivity to antibiotics and causes of the post-neurosurgical meningitis infections in our cohort.
Conclusion
Post-neurosurgical meningitis usually occurs in the autumn and winter of the year in our hospital. Gram-positive organisms, which are sensitive to compound sulfamethoxazole and vancomycin, are the most common causative pathogens of post-neurosurgical meningitis in the northern mainland of China.
Main results
Of the 6407 patients who underwent neurosurgical procedures during the study period, 146 developed post-neurosurgical meningitis and the overall incidence of meningitis was 2.28%. The incidence of meningitis was significantly higher in patients who underwent surgery in the autumn and winter than spring or summer (p=0.000). The most common organisms causing meningitis were Gram-positive bacteria, followed by the Klebsiella and Baumannii species. Compound sulfamethoxazole (52.6%) and vancomycin (10.5%) were the most active antibiotics against Gram-positive bacteria strains, whereas meropenem (43.8%) and polymyxin (18.8%) were active against Gram-negative bacillus strains.