Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Mechanism and surgical management of transsellar transsphenoidal encephalocele
First author：Zhijun Yang, Zhenmin Wang
Corresponding author：Pinan Liu
essential_information
- Person in charge：Zhijun Yang, Zhenmin Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190363
- Published time：2015-12-01
2015-12-01
Published articles
Journal：Journal of Clinical Neuroscience
Publication type: Original Article
IF(IF): 1.961
PMID: 26256066 Link To Pubmed Full text Download
Background And Purpose
Method
We retrospectively reviewed six patients who were treated in our hospital from October 2003 to September 2013; five male patients and one female, with an average age of 10 years (range: 2 - 28). We collected data on their general condition, medical history, clinical features, and outcomes. An endoscopic transsphenoidal approach was used for five patients, and one refused surgery. All patients had similar imaging findings, and their pituitary gland could not be seen on MRI.
Conclusion
This disease may result from pituitary dysplasia, and the symptoms develop as the patients grow. Surgical interventions can be helpful for symptom management, the optimal treatment being a transsphenoidal approach. Those patients with milder symptoms preoperatively have a better prognosis.
Main results
Five of the patients showed gradual disease progression. The clinical symptoms were endocrine disturbance (n=6), decreased visual acuity (n=5), dyspnea (n=3) and cerebrospinal fluid rhinorrhea (n=2). Three of the patients also had a cleft palate. Two patients suffered serious symptoms of fever, tachyarrhythmia, and electrolyte disturbance postoperatively. After a long follow-up period, the symptoms remained stable or improved in all patients postoperatively, but worsened in the patient who did not have a surgical intervention. No mortalities were recorded.