Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Classification based on mutations of TERT promoter and IDH characterizes subtypes in grade II/III gliomas.
First author：Pei Yang, Jinquan Cai
Corresponding author：Tao Jiang
essential_information
- Person in charge：Pei Yang, Jinquan Cai
- Data Sources： OTHERS
- Number of papers：OTHERS20190376
- Published time：2016-08-01
2016-08-01
Published articles
Journal：Neuro-Oncology
Publication type: Research Article
IF(IF): 12.3
PMID: 26957363 Link To Pubmed Full text Download
Background And Purpose
Method
Here we sequenced TERT promoter mutational status (TERTp-mut) in the DNA of 377 grade II/III gliomas and analyzed the clinical factors, molecular aberrations, and transcriptome profiles
Conclusion
Our results showed that TERTp-mut combined with IDH-mut allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.